Despite the tremendous advances in cancer treatment, resistance to chemotherapeutic
agents impedes higher success rates and accounts for major relapses in cancer therapy …

Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of
children, accounting for about 15% of childhood cancer-related mortality in the United …

Abstract Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs
but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report …

Background & Aims p53 mutations occur frequently in human HCC. Activation of the
mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is …

MYCN oncogene amplification is frequently observed in aggressive childhood
neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma …

Informative and realistic mouse models of high-risk neuroblastoma are central to
understanding mechanisms of tumour initiation, progression, and metastasis. They also play …

Aims: Increasing evidence links the abnormal expression of microRNAs and ATP-binding
cassette subfamily C member 4 (ABCC4) with tumor development and progression, as well …

Docetaxel is a major treatment for advanced prostate cancer (PCa); however, its resistance
compromises clinical effectiveness. Estrogen receptor-related receptor alpha (ERRα) …

Pancreatic cancer is one of the most lethal types of tumors with no effective therapy
available; is currently the third leading cause of cancer in developed countries; and is …

Multidrug resistance-associated protein 4 (MRP4), a member of the adenosine triphosphate
(ATP) binding cassette transporter family, pumps various molecules out of the cell and is …