Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Background Mitochondrial dysfunction and defects in oxidative metabolism are a
characteristic feature of many chronic illnesses not currently classified as mitochondrial …

Background: Current interventions for major depressive disorder (MDD) are suboptimal, and
only one third respond to them on initial treatment. Neuroplasticity theories are the basis for …

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and
oxidative stress, which are important factors contributing to the development of brain …

Depressive disorders can affect up to 350 million people worldwide, and in developed
countries, the percentage of patients with depressive disorders may be as high as 10 …

Importance Nucleic acid damage from oxidative stress (NA-OXS) may be a molecular
mechanism driving the severely increased morbidity and mortality from somatic causes in …

Although the etiology of ovarian cancer is not clear, certain factors are implicated in this
disease, such as ovulation, gonadotropic and steroid hormones, growth factors, cytokines …