Major tail proteins of bacteriophages of the order Caudovirales

M Zinke, GF Schröder, A Lange - Journal of Biological Chemistry, 2022 - ASBMB
Technological advances in cryo-EM in recent years have given rise to detailed atomic
structures of bacteriophage tail tubes—a class of filamentous protein assemblies that could …

Evolutionary and ecological role of extracellular contractile injection systems: from threat to weapon

CM Heiman, J Vacheron, C Keel - Frontiers in Microbiology, 2023 - frontiersin.org
Contractile injection systems (CISs) are phage tail-related structures that are encoded in
many bacterial genomes. These devices encompass the cell-based type VI secretion …

[HTML][HTML] Programmable protein delivery with a bacterial contractile injection system

J Kreitz, MJ Friedrich, A Guru, B Lash, M Saito… - Nature, 2023 - nature.com
Endosymbiotic bacteria have evolved intricate delivery systems that enable these organisms
to interface with host biology. One example, the extracellular contractile injection systems …

Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation

R Linares, CA Arnaud, G Effantin, C Darnault… - Science …, 2023 - science.org
Most bacteriophages present a tail allowing host recognition, cell wall perforation, and viral
DNA channeling from the capsid to the infected bacterium cytoplasm. The majority of tailed …

Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

GL Weiss, F Eisenstein, AK Kieninger, J Xu… - Nature …, 2022 - nature.com
Contractile injection systems (CISs) mediate cell–cell interactions by phage tail-like
structures, using two distinct modes of action: extracellular CISs are released into the …

Action of a minimal contractile bactericidal nanomachine

P Ge, D Scholl, NS Prokhorov, J Avaylon, MM Shneider… - Nature, 2020 - nature.com
R-type bacteriocins are minimal contractile nanomachines that hold promise as precision
antibiotics,,–. Each bactericidal complex uses a collar to bridge a hollow tube with a …

Cytoplasmic contractile injection systems mediate cell death in Streptomyces

B Casu, JW Sallmen, S Schlimpert, M Pilhofer - Nature Microbiology, 2023 - nature.com
Contractile injection systems (CIS) are bacteriophage tail-like structures that mediate
bacterial cell–cell interactions. While CIS are highly abundant across diverse bacterial …

Live cell dynamics of production, explosive release and killing activity of phage tail-like weapons for Pseudomonas kin exclusion

J Vacheron, CM Heiman, C Keel - Communications biology, 2021 - nature.com
Interference competition among bacteria requires a highly specialized, narrow-spectrum
weaponry when targeting closely-related competitors while sparing individuals from the …

The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins

AM Geller, I Pollin, D Zlotkin, A Danov… - Nature …, 2021 - nature.com
Abstract The extracellular Contractile Injection System (eCIS) is a toxin-delivery particle that
evolved from a bacteriophage tail. Four eCISs have previously been shown to mediate …

Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

J Xu, CF Ericson, YW Lien, FUN Rutaganira… - Nature …, 2022 - nature.com
Contractile injection systems (CISs) are phage tail-like nanomachines, mediating bacterial
cell–cell interactions as either type VI secretion systems (T6SSs) or extracellular CISs …