Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …

The growing prevalence of deadly microbes with resistance to previously life-saving drug
therapies is a dire threat to human health. Detection of low abundance pathogen sequences …

Importance Intermittent preventive therapy with sulfadoxine-pyrimethamine to control
malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those …

Plasmodium falciparum parasites that are resistant to artemisinins have been detected in
Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13 …

Adaptation in response to selection on polygenic phenotypes may occur via subtle allele
frequencies shifts at many loci. Current population genomic techniques are not well posed to …

Artemisinin resistance (AR) emerged in South East Asia 13 years ago and the identification
of the resistance conferring molecular marker, Plasmodium falciparum Kelch 13 (Pfk13), 7 …

Background The epidemiology of malaria makes surveillance-based methods of estimating
its disease burden problematic. Cartographic approaches have provided alternative malaria …

Summary Background Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine
threatens the antimalarial effectiveness of intermittent preventive treatment during …