A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

The mature capsids of human immunodeficiency virus type 1 (HIV-1) and other retroviruses
are fullerene shells, composed of the viral CA protein, that enclose the viral genome and …

The mature capsids of HIV and other retroviruses organize and package the viral genome
and its associated enzymes for delivery into host cells. The HIV capsid is a fullerene cone: a …

The major structural components of HIV are synthesized as a 55-kDa polyprotein, Gag.
Particle formation is driven by the self-assembly of Gag into a curved hexameric lattice, the …

The capsids of mature retroviruses perform the essential function of organizing the viral
genome for efficient replication. These capsids are modeled as fullerene structures …

Mature HIV-1 particles contain conical-shaped capsids that enclose the viral RNA genome
and perform essential functions in the virus life cycle. Previous structural analysis of two-and …

HIV forms spherical, membrane-enveloped, pleomorphic virions, 1,000–1,500 Å in diameter,
which contain two copies of its single-stranded, positive-sense RNA genome. Virus particles …

The emergence of resistance to existing classes of antiretroviral drugs necessitates finding
new HIV-1 targets for drug discovery. The viral capsid (CA) protein represents one such …

During the late stage of the viral life cycle, HIV-1 Gag assembles into a spherical immature
capsid, and undergoes budding, release, and maturation. Here we review events involved in …