Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

There is a lack of new antibiotics to combat drug-resistant bacterial infections that
increasingly threaten global health. The current pipeline of clinical-stage antimicrobials is …

Klebsiella pneumoniae is one of the most common pathogens responsible for infections,
including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence …

The emergence of novel antimicrobial resistance genes conferring resistance to last-resort
antimicrobials poses a serious challenge to global public health security. Recently, one …

Adrenal insufficiency in paediatric patients is mostly due to congenital adrenal hyperplasia
(CAH), a severe monogenic disease caused by steroid 21-hydroxylase deficiency (21-OHD …

Objectives This study aimed to determine the molecular mechanisms of linezolid-resistant
enterococci (LRE) in swine slaughterhouses in China and apply the “One Health” …

Background Extended-spectrum β-lactamases (ESBLs) are enzymes that can render their
hosts resistant to various β-lactam antibiotics. CTX-M-type enzymes are the most prevalent …

Antibiotic resistance is a continuously increasing concern for public healthcare.
Understanding resistance mechanisms and their emergence is crucial for the development …

Bacterial memory refers to the phenomenon in which past experiences influence current
behaviors in response to changing environments. It serves as a crucial process that enables …

ABSTRACT Objectives To characterize two Escherichia coli strains isolated from a patient
pre-and post-treatment, using β-lactams and β-lactam/β-lactamase inhibitor combinations …