Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy
target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB …

Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths
worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is …

Clostridium difficile is an opportunistic diarrhoeal pathogen, and C. difficile infection (CDI)
represents a major health care concern, causing an estimated 15,000 deaths per year in the …

The changing epidemiology of Clostridium difficile infection over the past decades presents
a significant challenge in the management of C. difficile associated diseases. The …

Clostridium difficile is a Gram-positive spore-forming anaerobe and a major cause of
antibiotic-associated diarrhoea. Disruption of the commensal microbiota, such as through …

The viruses that infect bacteria, known as phages, are the most abundant biological entity on
earth. They play critical roles in controlling bacterial populations through phage-mediated …

Leveraging systems biology approaches, we illustrate how metabolically distinct species of
Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating …

Foodborne pathogenic bacteria present a crucial food safety issue. Conventional diagnostic
methods are time-consuming and can be only performed on previously produced food. The …

Clostridioides difficile is often resistant to the actions of antibiotics to treat other bacterial
infections and the resulting C. difficile infection (CDI) is among the leading causes of …

Clostridium difficile is the largest single cause of hospital-acquired infection in the United
States. A major risk factor for Clostridium difficile infection (CDI) is prior exposure to …