Structure and evolution of neuronal wiring receptors and ligands
One of the fundamental properties of a neuronal circuit is the map of its connections. The
cellular and developmental processes that allow for the growth of axons and dendrites …
cellular and developmental processes that allow for the growth of axons and dendrites …
Plexins: Navigating through the Neural Regulation and Brain Pathology
Plexins are a family of transmembrane receptors known for their diverse roles in neural
development, axon guidance, neuronal migration, synaptogenesis, and circuit formation …
development, axon guidance, neuronal migration, synaptogenesis, and circuit formation …
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion
During morphogenesis, molecular mechanisms that orchestrate biomechanical dynamics
across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in …
across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in …
Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease
Y Huang, M Wang, H Ni, J Zhang, A Li, B Hu… - Nature …, 2024 - nature.com
Communication between glial cells has a profound impact on the pathophysiology of
Alzheimer's disease (AD). We reveal here that reactive astrocytes control cell distancing in …
Alzheimer's disease (AD). We reveal here that reactive astrocytes control cell distancing in …
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2
C Junqueira Alves, T Hannah, S Sadia… - Nature …, 2025 - nature.com
Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate
how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted …
how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted …
Effects of HAR1 on cognitive function in mice and the regulatory network of HAR1 determined by RNA sequencing and applied bioinformatics analysis
L Zhang, S Lin, K Huang, A Chen, N Li, S Shen… - Frontiers in …, 2023 - frontiersin.org
Background: HAR1 is a 118-bp segment that lies in a pair of novel non-coding RNA genes. It
shows a dramatic accelerated change with an estimated 18 substitutions in the human …
shows a dramatic accelerated change with an estimated 18 substitutions in the human …
A large reverse-genetic screen identifies numerous regulators of testis nascent myotube collective cell migration and collective organ sculpting
MC Bischoff, JE Norton, EA Munguia… - Molecular Biology of …, 2025 - molbiolcell.org
Collective cell migration is critical for morphogenesis, homeostasis, and wound healing.
Migrating mesenchymal cells form tissues that shape the body's organs. We developed a …
Migrating mesenchymal cells form tissues that shape the body's organs. We developed a …
Acerca del origen de los organismos multicelulares y la aparición de la diferenciación celular
F Castro-Muñozledo - Revista de Educación Bioquímica, 2024 - medigraphic.com
The origin of multicellularity, and consequently, the origin of specialized functions in the cells
that constitute an organism, are issues of great interest to understand the evolutionary …
that constitute an organism, are issues of great interest to understand the evolutionary …
Gene regulatory programs in the life history of Salpingoeca rosetta
MR Fumagalli, S Zapperi, CAM La Porta - bioRxiv, 2023 - biorxiv.org
The choanoflagellate Salpingoeca rosetta can differentiate into at least five morphologically
and behaviorally distinct cell types during its lifetime, going from individual motile cells to …
and behaviorally distinct cell types during its lifetime, going from individual motile cells to …
[PDF][PDF] Identify the regulatory network of LncRNA HAR1A in neurological development by RNA-Sequencing and bioinformatics analysis.
L Zhang, SM Lin, N Li, K Huang, SH Shen, Z Zheng… - 2022 - scholar.archive.org
Background: LncRNA HAR1A, which is explicitly expressed in Cajal-Retzius neurons (CRs),
has been reported to be related to the development of the human brain. As one of the …
has been reported to be related to the development of the human brain. As one of the …