[HTML][HTML] The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms
The upcoming 5th edition of the World Health Organization (WHO) Classification of
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers …
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers …
A summary of the inaugural WHO classification of pediatric tumors: transitioning from the optical into the molecular era
SM Pfister, M Reyes-Múgica, JKC Chan, H Hasle… - Cancer discovery, 2022 - AACR
Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …
within a collaboration between the World Health Organization (WHO), the Society for …
[HTML][HTML] The longitudinal dynamics and natural history of clonal haematopoiesis
MA Fabre, JG de Almeida, E Fiorillo, E Mitchell… - Nature, 2022 - nature.com
Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …
with age, including in the haematopoietic system, where the phenomenon is termed clonal …
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes
Abstract Germline SAMD9 and SAMD9L mutations (SAMD9/9L mut) predispose to
myelodysplastic syndromes (MDS) with propensity for somatic rescue. In this study, we …
myelodysplastic syndromes (MDS) with propensity for somatic rescue. In this study, we …
[HTML][HTML] A new genomic framework to categorize pediatric acute myeloid leukemia
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …
driver alterations, many of which are underrepresented in the current classification schemas …
Advances in germline predisposition to acute leukaemias and myeloid neoplasms
JM Klco, CG Mullighan - Nature Reviews Cancer, 2021 - nature.com
Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …
development of acute leukaemias and other haematopoietic diseases, it has become …
Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages
S Feurstein, AM Trottier, N Estrada-Merly… - Blood, The Journal …, 2022 - ashpublications.org
The frequency of pathogenic/likely pathogenic (P/LP) germ line variants in patients with
myelodysplastic syndrome (MDS) diagnosed at age 40 years or less is 15% to 20 …
myelodysplastic syndrome (MDS) diagnosed at age 40 years or less is 15% to 20 …
[HTML][HTML] Sequencing of human genomes with nanopore technology
Whole-genome sequencing (WGS) is becoming widely used in clinical medicine in
diagnostic contexts and to inform treatment choice. Here we evaluate the potential of the …
diagnostic contexts and to inform treatment choice. Here we evaluate the potential of the …
Myelodysplastic syndromes
M Cazzola - New England Journal of Medicine, 2020 - Mass Medical Soc
Myelodysplastic Syndromes MDS are clonal hematopoietic disorders involving morphologic
defects and peripheral-blood cytopenias, with a risk of progression to acute myeloid …
defects and peripheral-blood cytopenias, with a risk of progression to acute myeloid …