Bottom‐up synthetic biology is the science of building systems that mimic the structure and
function of living cells from scratch. To do this, researchers combine tools from chemistry …

The origin of life is still one of humankind's great mysteries. At the transition between
nonliving and living matter, protocells, initially featureless aggregates of abiotic matter, gain …

The past decades have witnessed the evolution of electronic and photonic integrated
circuits, from application specific to programmable,. Although liquid-phase DNA circuitry …

Isothermal autocatalytic DNA circuits have been proven to be versatile and powerful
biocomputing platforms by virtue of their self-sustainable and self-accelerating reaction …

The design and construction of synthetic therapeutic protocells capable of establishing
cognate chemical communication channels with living cells is an important challenge for …

Early and precise cancer diagnosis substantially improves patient survival. Recent work has
revealed that the levels of multiple microRNAs in serum are informative as biomarkers for …

Although the complexity of synthetic cells has continued to increase in recent years,
chemical communication between protocell models and living organisms remains a key …

Conspectus Cells have evolved to be self-sustaining compartmentalized systems that
consist of many thousands of biomolecules and metabolites interacting in complex cycles …

The design of compartmentalized colloids that exhibit biomimetic properties is providing
model systems for developing synthetic cell-like entities (protocells). Inspired by the cell …

Coacervates droplets have long been considered as potential protocells to mimic living
cells. However, these droplets lack a membrane and are prone to coalescence, limiting their …