The complete connectome of a learning and memory centre in an insect brain
Associating stimuli with positive or negative reinforcement is essential for survival, but a
complete wiring diagram of a higher-order circuit supporting associative memory has not …
complete wiring diagram of a higher-order circuit supporting associative memory has not …
[HTML][HTML] Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems
The brain of Drosophila melanogaster is comprised of some 100,000 neurons, 127 and 80
of which are dopaminergic and serotonergic, respectively. Their activity regulates behavioral …
of which are dopaminergic and serotonergic, respectively. Their activity regulates behavioral …
[HTML][HTML] Modelling learning and memory in drosophila to understand intellectual disabilities
V Mariano, T Achsel, C Bagni, AK Kanellopoulos - Neuroscience, 2020 - Elsevier
Neurodevelopmental disorders (NDDs) include a large number of conditions such as Fragile
X syndrome, autism spectrum disorders and Down syndrome, among others. They are …
X syndrome, autism spectrum disorders and Down syndrome, among others. They are …
A connectome of a learning and memory center in the adult Drosophila brain
Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …
Recurrent architecture for adaptive regulation of learning in the insect brain
Dopaminergic neurons (DANs) drive learning across the animal kingdom, but the upstream
circuits that regulate their activity and thereby learning remain poorly understood. We …
circuits that regulate their activity and thereby learning remain poorly understood. We …
Circuits for integrating learned and innate valences in the insect brain
Animal behavior is shaped both by evolution and by individual experience. Parallel brain
pathways encode innate and learned valences of cues, but the way in which they are …
pathways encode innate and learned valences of cues, but the way in which they are …
[HTML][HTML] Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila
T Saumweber, A Rohwedder, M Schleyer… - Nature …, 2018 - nature.com
The brain adaptively integrates present sensory input, past experience, and options for
future action. The insect mushroom body exemplifies how a central brain structure brings …
future action. The insect mushroom body exemplifies how a central brain structure brings …
[HTML][HTML] Suppression of dopamine neurons mediates reward
Massive activation of dopamine neurons is critical for natural reward and drug abuse. In
contrast, the significance of their spontaneous activity remains elusive. In Drosophila …
contrast, the significance of their spontaneous activity remains elusive. In Drosophila …
Connectomics and function of a memory network: the mushroom body of larval Drosophila
AS Thum, B Gerber - Current opinion in neurobiology, 2019 - Elsevier
Highlights•The connectome of the mushroom body memory network revealed unexpected
complexity.•The mushroom body integrates input, valence, and output within and across …
complexity.•The mushroom body integrates input, valence, and output within and across …
[HTML][HTML] Useful road maps: studying Drosophila larva's central nervous system with the help of connectomics
C Eschbach, M Zlatic - Current Opinion in Neurobiology, 2020 - Elsevier
Highlights•Drosophila larva enables combining comprehensive synapse resolution
connectivity maps with cellular-resolution activity maps and behavior maps.•This approach …
connectivity maps with cellular-resolution activity maps and behavior maps.•This approach …