Cognition is defined as the brain's ability to acquire, process, store, and retrieve information.
Pain has been described as an unpleasant sensory or emotional experience, and for …

The opioid system regulates affective processing, including pain, pleasure, and reward.
Restricting the role of this system to hedonic modulation may be an underestimation …

Since the serendipitous discovery of the first class of modern antidepressants in the 1950's,
all pharmacotherapies approved by the Food and Drug Administration for major depressive …

Major depressive disorder (MDD) remains one of the leading causes of disability and
functional impairment worldwide. Current antidepressant therapeutics require weeks to …

Both depression and rheumatoid arthritis (RA) have a very high comorbidity rate. A bilateral
association is estimated to increase the mutual risk and the common denominator is …

In spite of the increasing epidemic of pharmaceutical opioids (codeine and tramadol) misuse
and abuse among the adolescents, little is known about the neurotoxic consequences of the …

6, 14-ethenomorphinans are semisynthetic opiate derivatives containing an ethylene bridge
between positions 6 and 14 in ring-C of the morphine skeleton that imparts a rigid molecular …

Estrogens exert extensive influences on the nervous system besides their well-known roles
in regulation of reproduction and metabolism. Estrogens act via the nuclear receptor ERα …

Substance use disorders (SUD) may emerge from an individual's attempt to limit negative
affective states and symptoms linked to stress. Indeed, SUD is highly comorbid with chronic …

We aimed to examine the association between opioid use and the development of dementia
in patients with chronic non-cancer pain in South Korea. Data were extracted from the …