Conspectus Bridged and fused rings are commonly found in biologically important
molecules. Current tactics to construct these ring systems are primarily based on stepwise …

In this review, synthetic and mechanistic aspects of key methodologies that exploit C–C
single-bond cleavage of strained ring systems are highlighted. The focus is on transition …

Transition metal (TM)‐catalyzed difunctionalization of unactivated olefins with two carbon‐
based entities is a powerful method to construct complex molecular architectures rapidly …

The transition-metal-catalyzed “cut and sew” transformation has recently emerged as a
useful strategy for preparing complex molecular structures. After oxidative addition of a …

The current understanding of ligand effects in transition metal catalysis is mostly based on
the analysis of catalyst–substrate through-bond and through-space interactions, with the …

C− C bond activation has emerged as an increasingly useful approach for constructing
complex molecular scaffolds through unusual bond-disconnection strategies. As a common …

We describe an open-source computational toolkit (AARON: An Automated Reaction
Optimizer for New catalysts) that automates the quantum mechanical geometry optimization …

An asymmetric 1, 2-dicarbofunctionalization of unactivated alkenes with aryl iodides and
aryl/alkenylboronic esters under nickel/bioxazoline catalysis is disclosed. A wide array of …

We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid
pinacol esters. The reaction is triggered by oxidative addition of an activated amide C–N …

Herein, a straightforward and efficient method to obtain 3a, 7a-dihydroxy hexahydro-4H-
indol-4-ones via Ru (III)-catalyzed alkenyl C (sp2)–H bond functionalization/[3+ 2] …