Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is
achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial …

Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between
both organelles, but their role in normal and diseased human neurons remains unknown. In …

Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …

Calcium (Ca2+) homeostasis is essential for neuronal function and survival. Altered Ca2+
homeostasis has been consistently observed in neurological diseases. How Ca2+ …

Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …

The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …

The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …