Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
Metal-involving synthesis and reactions of oximes
DS Bolotin, NA Bokach, MY Demakova… - Chemical …, 2017 - ACS Publications
This review classifies and summarizes the past 10–15 years of advancements in the field of
metal-involving (ie, metal-mediated and metal-catalyzed) reactions of oximes. These …
metal-involving (ie, metal-mediated and metal-catalyzed) reactions of oximes. These …
Recent advancement of piperidine moiety in treatment of cancer-A review
Piperidine is an important pharmacophore, a privileged scaffold and an excellent
heterocyclic system in the field of drug discovery which provides numerous opportunities in …
heterocyclic system in the field of drug discovery which provides numerous opportunities in …
Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives
J Guillon, A Cohen, NM Gueddouda… - Journal of enzyme …, 2017 - Taylor & Francis
Novel series of bis-and tris-pyrrolo [1, 2-a] quinoxaline derivatives 1 were synthesized and
tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium …
tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium …
N,N-Dimethylformamide as Carbon Synthons for the Synthesis of N-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones
S Li, J Ren, C Ding, Y Wang, C Ma - The Journal of Organic …, 2021 - ACS Publications
N, N-dimethylformamide (DMF) as synthetic precursors contributing especially the methyl,
acyl, and amino groups has played a significant role in heterocycle syntheses and …
acyl, and amino groups has played a significant role in heterocycle syntheses and …
New achievements in the synthesis of pyrrolo[1,2-a]quinoxalines
AA Kalinin, LN Islamova, GM Fazleeva - Chemistry of Heterocyclic …, 2019 - Springer
This review article describes methods for the preparation of pyrrolo [1, 2-a] quinoxalines,
covering literature sources from the last 10 years. The attention was largely paid to new …
covering literature sources from the last 10 years. The attention was largely paid to new …
Auto‐Tandem Catalysis: Activation of Multiple, Mechanistically Distinct Process by a Single Catalyst
JE Camp - European Journal of Organic Chemistry, 2017 - Wiley Online Library
Auto‐tandem catalysis (ATC) is a powerful method for the synthesis of heterocycles and
carbocycles as well as acyclic compounds. The process is defined as a single reagent …
carbocycles as well as acyclic compounds. The process is defined as a single reagent …
NCS-promoted thiocyanation and selenocyanation of pyrrolo [1, 2-a] quinoxalines
Z Yang, J He, Y Wei, W Li, P Liu, J Zhao… - Organic & Biomolecular …, 2020 - pubs.rsc.org
An efficient NCS-promoted thiocyanation of pyrrolo [1, 2-a] quinoxalines with NH4SCN or
KSCN is described. A series of diverse 1-thiocyanatopyrrolo [1, 2-a] quinoxalines were …
KSCN is described. A series of diverse 1-thiocyanatopyrrolo [1, 2-a] quinoxalines were …
Crystal structure, DFT studies, Hirshfeld surface and energy framework analysis of 4-(5-nitro-thiophen-2-yl)-pyrrolo [1, 2-a] quinoxaline: A potential SARS-CoV-2 main …
Abstract The title compound 4-(5-nitro-thiophen-2-yl)-pyrrolo [1, 2-a] quinoxaline (5NO 2
TAAPP) was obtained by a straightforward catalyst-free reaction of 5-nitro-2-thiophene …
TAAPP) was obtained by a straightforward catalyst-free reaction of 5-nitro-2-thiophene …
Copper-catalyzed synthesis of polysubstituted pyrroles through [3+ 1+ 1] cycloaddition reaction of nitrones and isocyanides
Z Tian, J Xu, B Liu, Q Tan, B Xu - Organic letters, 2018 - ACS Publications
An efficient, copper-catalyzed [3+ 1+ 1] cycloaddition reaction was developed for the
expedient synthesis of pharmacologically interesting polysubstituted pyrroles from easily …
expedient synthesis of pharmacologically interesting polysubstituted pyrroles from easily …