Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Metal-involving synthesis and reactions of oximes

DS Bolotin, NA Bokach, MY Demakova… - Chemical …, 2017 - ACS Publications
This review classifies and summarizes the past 10–15 years of advancements in the field of
metal-involving (ie, metal-mediated and metal-catalyzed) reactions of oximes. These …

Recent advancement of piperidine moiety in treatment of cancer-A review

P Goel, O Alam, MJ Naim, F Nawaz, M Iqbal… - European journal of …, 2018 - Elsevier
Piperidine is an important pharmacophore, a privileged scaffold and an excellent
heterocyclic system in the field of drug discovery which provides numerous opportunities in …

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives

J Guillon, A Cohen, NM Gueddouda… - Journal of enzyme …, 2017 - Taylor & Francis
Novel series of bis-and tris-pyrrolo [1, 2-a] quinoxaline derivatives 1 were synthesized and
tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium …

N,N-Dimethylformamide as Carbon Synthons for the Synthesis of N-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones

S Li, J Ren, C Ding, Y Wang, C Ma - The Journal of Organic …, 2021 - ACS Publications
N, N-dimethylformamide (DMF) as synthetic precursors contributing especially the methyl,
acyl, and amino groups has played a significant role in heterocycle syntheses and …

New achievements in the synthesis of pyrrolo[1,2-a]quinoxalines

AA Kalinin, LN Islamova, GM Fazleeva - Chemistry of Heterocyclic …, 2019 - Springer
This review article describes methods for the preparation of pyrrolo [1, 2-a] quinoxalines,
covering literature sources from the last 10 years. The attention was largely paid to new …

Auto‐Tandem Catalysis: Activation of Multiple, Mechanistically Distinct Process by a Single Catalyst

JE Camp - European Journal of Organic Chemistry, 2017 - Wiley Online Library
Auto‐tandem catalysis (ATC) is a powerful method for the synthesis of heterocycles and
carbocycles as well as acyclic compounds. The process is defined as a single reagent …

NCS-promoted thiocyanation and selenocyanation of pyrrolo [1, 2-a] quinoxalines

Z Yang, J He, Y Wei, W Li, P Liu, J Zhao… - Organic & Biomolecular …, 2020 - pubs.rsc.org
An efficient NCS-promoted thiocyanation of pyrrolo [1, 2-a] quinoxalines with NH4SCN or
KSCN is described. A series of diverse 1-thiocyanatopyrrolo [1, 2-a] quinoxalines were …

Crystal structure, DFT studies, Hirshfeld surface and energy framework analysis of 4-(5-nitro-thiophen-2-yl)-pyrrolo [1, 2-a] quinoxaline: A potential SARS-CoV-2 main …

KM Divya, DP Savitha, GA Krishna, TM Dhanya… - Journal of Molecular …, 2022 - Elsevier
Abstract The title compound 4-(5-nitro-thiophen-2-yl)-pyrrolo [1, 2-a] quinoxaline (5NO 2
TAAPP) was obtained by a straightforward catalyst-free reaction of 5-nitro-2-thiophene …

Copper-catalyzed synthesis of polysubstituted pyrroles through [3+ 1+ 1] cycloaddition reaction of nitrones and isocyanides

Z Tian, J Xu, B Liu, Q Tan, B Xu - Organic letters, 2018 - ACS Publications
An efficient, copper-catalyzed [3+ 1+ 1] cycloaddition reaction was developed for the
expedient synthesis of pharmacologically interesting polysubstituted pyrroles from easily …