Upon antigen recognition, naive T cells undergo rapid expansion and activation. The energy
requirements for this expansion are formidable, and T‐cell activation is accompanied by …

Enzymes are dynamic entities, and their dynamic properties are clearly linked to their
biological function. It follows that dynamics ought to play an essential role in enzyme …

Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing,
offering levels of selectivity and tunability that can dramatically improve chemical synthesis …

Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for
the treatment of COVID-19. Given the potential high demand and urgency for this compound …

T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox
demands following antigen stimulation. To fulfil these needs, effector T cells must adapt to …

Phosphorylation is an essential chemical reaction for life. This reaction generates
fundamental cell components, including building blocks for RNA and DNA, phospholipids for …

Neuronal activity creates an intense energy demand that must be met by rapid metabolic
responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell …

Comparative genomics is the cornerstone of identification of gene functions. The immense
number of living organisms precludes experimental identification of functions except in a …

Abstract β-Nicotinamide mononucleotide (NMN) is, one of the nucleotide compounds, a
precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop …

Borrelia burgdorferi (Bb) adapts to its arthropod and mammalian hosts by altering its
transcriptional and antigenic profiles in response to environmental signals associated with …