Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials
C Granchi, S Bertini, M Macchia… - Current medicinal …, 2010 - ingentaconnect.com
In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of
anaerobic glycolysis, by catalyzing the reduction of pyruvate into lactate. This enzyme has …
anaerobic glycolysis, by catalyzing the reduction of pyruvate into lactate. This enzyme has …
Synthesis, characterization, crystal structures, DFT, TD-DFT, molecular docking and DNA binding studies of novel copper (II) and zinc (II) complexes bearing …
H Kargar, R Behjatmanesh-Ardakani, V Torabi… - Polyhedron, 2021 - Elsevier
A novel series of transition metal complexes of Cu (II) and Zn (II), including:[Cu (L 1) 2]:
C1,[Cu (L 2) 2]: C2,[Cu (L 3) 2]: C3,[Cu (L 4) 2]: C4,[Zn (L 1) 2]: Z1,[Zn (L 2) 2]: Z2,[Zn (L 3) 2] …
C1,[Cu (L 2) 2]: C2,[Cu (L 3) 2]: C3,[Cu (L 4) 2]: C4,[Zn (L 1) 2]: Z1,[Zn (L 2) 2]: Z2,[Zn (L 3) 2] …
Warburg effect, lactate dehydrogenase, and radio/chemo-therapy efficacy
MI Koukourakis, A Giatromanolaki - International Journal of …, 2019 - Taylor & Francis
The anaerobic metabolism of glucose by cancer cells, even under well-oxygenated
conditions, has been documented by Otto Warburg as early as 1927. Micro-environmental …
conditions, has been documented by Otto Warburg as early as 1927. Micro-environmental …
[HTML][HTML] A novel Schiff base derived from the gabapentin drug and copper (II) complex: Synthesis, characterization, interaction with DNA/protein and cytotoxic activity
Z Shokohi-Pour, H Chiniforoshan… - … of Photochemistry and …, 2016 - Elsevier
A novel Schiff base [C 20 H 23 NO 3], has been prepared and characterized using FT-IR, UV–
vis, 1 H NMR spectroscopy, elemental analysis and X-ray crystallography. A copper (II) …
vis, 1 H NMR spectroscopy, elemental analysis and X-ray crystallography. A copper (II) …
Modulation of antioxidant enzymes, SIRT1 and NF‐κB by resveratrol and nicotinamide in alcohol‐aflatoxin B1‐induced hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide
and is associated with poor prognosis. The current study aimed to assess the therapeutic …
and is associated with poor prognosis. The current study aimed to assess the therapeutic …
Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy
Objectives: We assessed the expression and the prognostic role of lactate dehydrogenase 5
(LDH5, the major LDH isoenzyme involved in anaerobic glycolysis) in patients with …
(LDH5, the major LDH isoenzyme involved in anaerobic glycolysis) in patients with …
In vitro DNA interaction, topoisomerase I/II inhibition and cytotoxic properties of polymeric copper (II) complex bridged with perchlorate ion containing N4-type Schiff …
CG Topkaya, T Göktürk, T Hökelek, ES Cetin… - Journal of Molecular …, 2022 - Elsevier
Cu (II) complex containing p-Cl-isonitrosoacetophenone based on N 4-type Schiff base
ligand was synthesized and characterized by elemental analysis, FTIR, 1 H NMR, 13 C NMR …
ligand was synthesized and characterized by elemental analysis, FTIR, 1 H NMR, 13 C NMR …
Chiral halogenated Schiff base compounds: green synthesis, anticancer activity and DNA-binding study
M Ariyaeifar, HA Rudbari, M Sahihi, Z Kazemi… - Journal of Molecular …, 2018 - Elsevier
Eight enantiomerically pure halogenated Schiff base compounds were synthesized by
reaction of halogenated salicylaldehydes with 3-Amino-1, 2-propanediol (R or S) in water as …
reaction of halogenated salicylaldehydes with 3-Amino-1, 2-propanediol (R or S) in water as …
Mononuclear silver (I) complexes with 1, 7-phenanthroline as potent inhibitors of Candida growth
Mononuclear silver (I) complexes with 1, 7-phenanthroline (1, 7-phen),[Ag (NO 3-O, O′)(1,
7-phen-N7) 2](1) and [Ag (1, 7-phen-N7) 2] X, X= ClO 4−(2), CF 3 SO 3−(3), BF 4−(4) and …
7-phen-N7) 2](1) and [Ag (1, 7-phen-N7) 2] X, X= ClO 4−(2), CF 3 SO 3−(3), BF 4−(4) and …
Phosphatase-like activity, DNA binding, DNA hydrolysis, anticancer and lactate dehydrogenase inhibition activity promoting by a new bis–phenanthroline dicopper (II) …
S Anbu, M Kandaswamy, S Kamalraj… - Dalton …, 2011 - pubs.rsc.org
A new bis-phenanthroline dicopper (II) complex has been synthesized and characterized by
elemental analysis and spectroscopic methods. The molecular structure of the dinuclear Cu …
elemental analysis and spectroscopic methods. The molecular structure of the dinuclear Cu …