All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …

Single-walled carbon nanotubes (SWCNTs) with adsorbed single-stranded DNA (ssDNA)
are applied as sensors to investigate biological systems, with potential applications ranging …

RNAs fold into defined tertiary structures to function in critical biological processes. While
quantitative models can predict RNA secondary structure stability, we are still unable to …

Highlights•Predictive understanding of RNA kinetics and thermodynamics requires energy
landscape determination.•Junctions determine relative orientations of helices and …

The intricate interplay between DNA and proteins is key for biological functions such as DNA
replication, transcription and repair. Dynamic nanoscale observations of DNA structural …

Accelerating discoveries of non-coding RNA (ncRNA) in myriad biological processes pose
major challenges to structural and functional analysis. Despite progress in secondary …

Clustered apurinic/apyrimidinic (AP; abasic) DNA lesions produced by ionizing radiation are
by far more cytotoxic than isolated AP lesion entities. The structure and dynamics of a series …

Accurate determination of molecular distances is fundamental to understanding the
structure, dynamics, and conformational ensembles of biological macromolecules. Here we …

With the growing number of crystal structures of RNA and RNA–protein complexes, a critical
next step is understanding the dynamic solution behavior of these entities in terms of …

The DNA four-way (Holliday) junction is the central intermediate of genetic recombination,
yet key aspects of its conformational and thermodynamic properties remain unclear. While …