The role of androgen receptor (AR) activation and expression is well understood in prostate
cancer. In breast cancer, expression and activation of AR is increasingly recognized for its …

Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …

Abstract Background Prostate cancer (PCa) is an age-related malignancy in men with a high
incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many …

Cellular senescence is a natural tumor suppression mechanism defined by a stable
proliferation arrest. In the context of cancer treatment, cancer cell therapy-induced …

Background Prostate-specific membrane antigen (PSMA)-directed radioligand therapy
(RLT) is a promising yet not curative approach in castration-resistant (CR) prostate cancer …

PURPOSE We sought to investigate whether enzalutamide (ENZA), without concurrent
androgen deprivation therapy, increases freedom from prostate-specific antigen (PSA) …

Simple Summary Prostate cancer is the second most common cancer in males. In prostate
cancer cells, androgens bind and activate the intracellular mediator called Androgen …

Dielectric spectroscopy is a nondestructive method to characterize dielectric properties by
measuring impedance data over a frequency spectrum. This method has been widely used …

Blocking androgen receptor (AR) transcriptional activity by androgen deprivation therapy
(ADT) improves the response to radiotherapy for intermediate and high risk prostate cancer …