The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

The human selenoprotein family contains 25 members that share the common feature of
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …

The regeneration of adult skeletal muscle after injury is primarily initiated by satellite cells
(SCs), but the regulatory mechanisms of cells committed to myogenic differentiation remain …

Although selenocysteine selenenic acids (Sec–SeOHs) have been recognized as key
intermediates in the catalytic cycle of glutathione peroxidase (GPx), examples of the direct …

The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative
stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se …

Cardiovascular diseases represent one of the most important health problems of developed
countries. One of the main actors involved in the onset and development of cardiovascular …

Many of the 25 members of the selenoprotein family function as enzymes that utilize their
selenocysteine (Sec) residues to catalyze redox-based reactions. However, some …

Cellular metabolism is inherently linked to the production of oxidizing by-products, including
reactive oxygen species (ROS) hydrogen peroxide (H 2 O 2). When present in excess, H 2 O …

Peptide ligation chemistry has revolutionized protein science by facilitating access to
synthetic proteins. Here, we describe the development of additive-free ligation …

Selenoprotein S (selenos) is a small, intrinsically disordered membrane protein that is
associated with various cellular functions, such as inflammatory processes, cellular stress …