Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …

Compelling evidence supports the concepts that gut microbiota actively promotes weight
gain and fat accumulation and sustains, indirectly, a condition of low-grade inflammation …

Aims/hypothesis While it is well known that diet-induced obesity causes insulin resistance,
the precise mechanisms underpinning the initiation of insulin resistance are unclear. To …

Skeletal muscles contain resident immune cell populations and their abundance and type is
altered in inflammatory myopathies, endotoxemia or different types of muscle injury/insult …

Chronic inflammation is an important etiology underlying obesity-related disorders such as
insulin resistance and type 2 diabetes, and recent findings indicate that the macrophage can …

A low plasma level of HDL cholesterol is an atherosclerotic risk factor; however, emerging
evidence suggests that low HDL levels might also contribute to the pathophysiology of type …

A lack of physical activity is linked to the development of many chronic diseases. It is now
well established that the immune system and inflammation play a central role in the …

OBJECTIVE Insulin resistance associates with chronic inflammation, and participatory
elements of the immune system are emerging. We hypothesized that bacterial elements …

There is increasing evidence showing that chronic inflammation is an important pathogenic
mediator of the development of type 2 diabetes (T2D). It is now generally accepted that …

Insulin resistance is a condition of reduced biological response to insulin. Growing evidence
indicates the role of the chronic low-grade inflammatory response in the pathogenesis of …