Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …

The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …

In association with therapeutic drug monitoring of immunosuppressive drugs,
pharmacogenetics has rapidly emerged as an additional tool to refine dose selection or …

What is known and objectives Tacrolimus (TAC) is a first‐line immunosuppressant which is
used to prevent transplant rejection after solid organ transplantation (SOT). However, it has …

Aims Tacrolimus (TAC) is one of the most successful immunosuppressive drugs in
transplantation. Its pharmacokinetics (PK) and pharmacogenetics (PG) have been …

Background Common genetic variants of the enzymes and efflux pump involved in
tacrolimus disposition have been associated with calcineurin inhibitor nephrotoxicity, but …

Although immunoassays are widely used for therapeutic drug monitoring of various
immunosuppressants, a major limitation of these immunoassays is the significant cross …

Racial differences among kidney transplant recipients may impact the total daily tacrolimus
dose required to achieve therapeutic tacrolimus concentrations. Previous studies suggest …

Tacrolimus has been widely used in membranous nephropathy in recent years. The drug
interactions of the coadministration of tacrolimus with omeprazole in CYP3A5 nonexpresser …

ABSTRACT Introduction. Introduction. Biliary complications can cause morbidity, graft loss,
and mortality after liver transplantation. The most troublesome biliary complications are …