Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns
remain about the potential adverse effects, particularly vascular occlusive events, that may …

Objective To assess the effect of tranexamic acid on blood transfusion, thromboembolic
events, and mortality in surgical patients. Design Systematic review and meta-analysis. Data …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

1NHS Blood and Transplant, 2Imperial College Healthcare NHS Trust, London, 3University
College Hospitals NHS Trust, London, 4Serious Hazards of Transfusion, NHS Blood and …

Tranexamic acid, a synthetic derivative of the amino acid lysine, is an antifibrinolytic agent
that acts by binding to plasminogen and blocking the interaction of plasmin (ogen) with …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Blood loss and subsequent transfusions are associated with major morbidity and mortality.
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …

Uncontrolled massive bleeding with subsequent derangement of the coagulation system is a
major challenge in the management of both surgical and seriously injured patients. Under …

Background Tranexamic acid (TXA) reduces blood transfusion in surgery but the extent of
the reduction in blood loss and how it relates to the dose of TXA is unclear. Methods A …

BACKGROUND Craniosynostosis is a condition in which 2 or more of the skull bones fuse
prematurely. The spectrum of the disorder most commonly involves the closure of a single …