The purpose of this review is to summarize the research progress of PI3K/Akt signaling
pathway in erythropoiesis and glycolysis. Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway is activated in the majority of human cancers. This pathway is known to play a key …

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

The programmed cell death that occurs as part of normal mammalian development was first
observed nearly a century ago (Collin 1906). It has since been established that …

During hypoxia, hypoxia-inducible factor-1α (HIF-1α) is required for induction of a variety of
genes including erythropoietin and vascular endothelial growth factor. Hypoxia increases …

Angiogenesis is a complex process depending on the coordination of many regulators and
there by activating angiogenic switch. Recent advances in understanding of angiogenic …

▪ Abstract Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS
transcription factor consisting of HIF-1α and HIF-1β subunits. HIF-1α expression and HIF-1 …

▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential
homeostatic responses to reduced O2 availability in mammals. Recent studies have …

Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-
kinase (PI3K), AKT (protein kinase B), and its effector FKBP-rapamycin-associated protein …