Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …

Taxane‐derived drugs are antineoplastic agents used for the treatment of highly common
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …

This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic
phytochemical present in Cannabis sativa, on the cognitive and emotional impairments …

Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40
isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic …

Early life stress is associated with various complications. Auraptene has significant
antioxidant and anti-inflammatory effects. This study aimed to assess the probable …

Disturbances in mitochondrial biogenesis and bioenergetics, combined with
neuroinflammation, play cardinal roles in the cognitive impairment during aging that is …

Despite the advancements in medical sciences in last few decades, we are yet to develop
promising therapeutics for stroke, which is one of the current global non-communicative …

Glioblastomas are universally fatal cancers and contain self-renewing glioblastoma stem
cells (GSCs) that initiate tumors. Traditional anticancer drug discovery based on in vitro …

Aims Cerebral ischemia can lead to anxiety and cognitive impairment due to the loss of
hippocampal neurons. Facilitation of endogenous neurogenesis in the hippocampus is a …

Pharmacological interventions that selectively activate serotonin 5-hydroxytryptramine-1A (5-
HT 1A) heteroreceptors may prevent or attenuate the consequences of brain ischemic …