Biopharmaceutical applications of microbial polysaccharides as materials: A review

Y Song, S Li, H Gong, RCS Yip, H Chen - International Journal of Biological …, 2023 - Elsevier
Biological characteristics of natural polymers make microbial polysaccharides an excellent
choice for biopharmaceuticals. Due to its easy purifying procedure and high production …

Carbohydrate polymer-based bioadhesive formulations and their potentials for the treatment of ocular diseases: A review

X Tang, J Liu, R Yan, Q Peng - International Journal of Biological …, 2023 - Elsevier
Eyes are directly exposed to the outer environment and susceptible to infections, leading to
various ocular disorders. Local medication is preferred to treat eye diseases due to its …

[HTML][HTML] Injectable systems of chitosan in situ forming composite gel incorporating linezolid-loaded biodegradable nanoparticles for long-term treatment of bone …

RK Wassif, SA Elkheshen, RN Shamma… - Drug Delivery and …, 2024 - Springer
The objective of the current study was to create an efficient, minimally invasive combined
system comprising in situ forming hydrogel loaded with both spray-dried polymeric …

[HTML][HTML] Formulation and evaluation of moxifloxacin loaded bilosomes in-situ gel: optimization to antibacterial evaluation

A Zafar, OA Alsaidan, SS Imam, M Yasir, KS Alharbi… - Gels, 2022 - mdpi.com
In this study, moxifloxacin (MX)-loaded bilosome (BS) in situ gel was prepared to improve
ocular residence time. MX-BSs were prepared using the thin-film hydration method. They …

Formulation and optimization of cationic nanoemulsions for enhanced ocular delivery of dorzolamide hydrochloride using Box-Behnken design: In vitro and in vivo …

AA Kassem, A Salama, AM Mohsen - Journal of Drug Delivery Science and …, 2022 - Elsevier
The present study was designed to develop dorzolamide HCl (DRZ) loaded cationic
nanoemulsions (CNEs) for enhanced ocular delivery. CNEs were prepared employing high …

In situ gelling microemulsion for topical ocular delivery of moxifloxacin and betamethasone

CO Cardoso, R Ferreira-Nunes, M Cunha-Filho… - Journal of Molecular …, 2022 - Elsevier
This article proposes an in situ gelling microemulsion for the ocular delivery of moxifloxacin
(MOX) combined with betamethasone (BET) for use as a topical formulation throughout the …

Chitosan with enhanced deprotonation for accelerated thermosensitive gelation with β-glycerophosphate

Y Liu, C Lang, Y Ding, S Sun, G Sun - European Polymer Journal, 2023 - Elsevier
Abstract Chitosan (CS)/β-sodium glycerophosphate (β-GP) gels have low temperature
sensitivity, which limits their biomedical application. The protonation and deprotonation of …

[HTML][HTML] Novel gels: an emerging approach for delivering of therapeutic molecules and recent trends

TK Sastri, VN Gupta, S Chakraborty, S Madhusudhan… - Gels, 2022 - mdpi.com
Gels are semisolid, homogeneous systems with continuous or discrete therapeutic
molecules in a suitable lipophilic or hydrophilic three-dimensional network base. Innovative …

Encapsulation of Triphasia trifolia extracts by pH and thermal dual-sensitive chitosan hydrogels for controlled release

NHN Do, TNA Huynh, TX Le, AC Ha, PK Le - Carbohydrate Polymers, 2023 - Elsevier
Recent studies have developed varied delivery systems incorporating natural compounds to
improve the limitations of plant extracts for clinical use while enabling their controlled …

Chitosan/sodium alginate/velvet antler blood peptides hydrogel promotes diabetic wound healing via regulating angiogenesis, inflammatory response and skin flora

M Hao, C Ding, S Sun, X Peng, W Liu - Journal of Inflammation …, 2022 - Taylor & Francis
Background Diabetic ulcer remains a clinical challenge due to impaired angiogenesis and
persistent inflammation, requiring new alternative therapies to promote tissue regeneration …