Circular RNAs in pulmonary hypertension: emerging biological concepts and potential mechanism

Q Wang, Y Sun, Q Zhao, W Wu, L Wang… - Animal Models and …, 2022 - Wiley Online Library
Circular RNAs (circRNAs) are endogenous RNAs with a covalently closed single‐stranded
transcript. They are a novel class of genomic regulators that are linked to many important …

The role of glutamine and glutaminase in pulmonary hypertension

S Wang, Y Yan, WJ Xu, SG Gong, XJ Zhong… - Frontiers in …, 2022 - frontiersin.org
Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome in which
pulmonary vascular resistance and pulmonary arterial pressure are increased due to …

Plasma metabolomics in the perioperative period of defect repair in patients with pulmonary arterial hypertension associated with congenital heart disease

Y He, Y Yan, J Chen, S Liu, L Hua, X Jiang… - Acta Pharmacologica …, 2022 - nature.com
The quality of life and survival rates of patients with pulmonary arterial hypertension
associated with congenital heart disease (CHD–PAH) have been greatly improved by defect …

Integrated metabolomics and mechanism to reveal the protective effect of kaempferol on pulmonary arterial hypertension

J Yi, X Wang, K Song, J Ren, H Che, H Yu… - Journal of Pharmaceutical …, 2022 - Elsevier
Currently, there have been breakthroughs in the study of the underlying mechanisms of
pulmonary arterial hypertension, but treatment is still challenging. The aim of this study was …

Metabolomics meets clinics: a multivariate analysis of plasma and urine metabolic signatures in pulmonary arterial hypertension

R Wawrzyniak, P Grešner, E Lewicka… - Journal of Proteome …, 2023 - ACS Publications
Pulmonary arterial hypertension (PAH) is a severe, multifactorial, and frequently
misdiagnosed disorder. The aim of this observational study was to compare the plasma and …

Implication of proliferation gene biomarkers in pulmonary hypertension

Y Yan, R Jiang, P Yuan, L Wen… - Animal Models and …, 2021 - Wiley Online Library
Abstract Objective/Background Proliferation is a widely recognized trigger for pulmonary
hypertension (PH), a life‐threatening, progressive disorder of pulmonary blood vessels. This …

Right ventricle remodeling metabolic signature in experimental pulmonary hypertension models of chronic hypoxia and monocrotaline exposure

T Hautbergue, F Antigny, A Boët, F Haddad, B Masson… - Cells, 2021 - mdpi.com
Introduction: Over time and despite optimal medical management of patients with pulmonary
hypertension (PH), the right ventricle (RV) function deteriorates from an adaptive to …

Interstage single ventricle heart disease infants show dysregulation in multiple metabolic pathways: targeted metabolomics analysis

BS Frank, L Khailova, J Dekermanjian, MB Mitchell… - JACC: Advances, 2023 - jacc.org
Background Infants with SVHD experience morbidity related to pulmonary vascular
inadequacy. Metabolomic analysis involves a systems biology approach to identifying novel …

Animal models of pulmonary hypertension due to left heart disease

SF Liu, Y Yan - Animal Models and Experimental Medicine, 2022 - Wiley Online Library
Pulmonary hypertension due to left heart disease (PH‐LHD) is regarded as the most
prevalent form of pulmonary hypertension (PH). Indeed, PH is an independent risk factor …

Metabolic reprogramming: A novel metabolic model for pulmonary hypertension

X Liu, L Zhang, W Zhang - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Pulmonary arterial hypertension, or PAH, is a condition that is characterized by pulmonary
artery pressures above 20 mmHg (at rest). In the treatment of PAH, the pulmonary vascular …