Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion
or disease of the somatosensory nervous system. Albeit the elucidation of numerous …

The key event in macroautophagy is the de novo formation of a new organelle called the
autophagosome which when complete, will have captured bits of cytoplasm within its double …

Targeting bromodomain and extra-terminal domain (BET) proteins has shown a promising
therapeutic effect on melanoma. The development of strategies to better kill melanoma cells …

Autophagy is a highly evolutionary conserved process that degrades cytosolic
macromolecules or damaged organelles (eg, mitochondria), as well as intracellular …

NLRP3 inflammasome, an intracellular multiprotein complex, can be activated by a range of
pathogenic microbes or endogenous hazardous chemicals. Its activation results in the …

Background Polycystic ovary syndrome (PCOS) is a complicated gynecological endocrine
disease that occurs in women of childbearing age. Protocatechuic acid is a phenol-rich …

Metformin is commonly used, but approximately 20% of patients experience gastrointestinal
intolerance, leading to medication discontinuation for unclear reasons and a lack of effective …

The expression of ULK1, a core protein of autophagy, is closely related to autophagic
activity. Numerous studies have shown that pathological abnormal expression of ULK1 is …

To find novel anti-inflammatory drugs, we screened anti-inflammatory compounds from 18
different types of Artemisia argyi seed extracts. The in vitro and in vivo anti-inflammatory …

Autophagy is a highly conserved process that utilizes lysosomes to selectively degrade a
variety of intracellular cargo, thus providing quality control over cellular components and …