Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

The activation of ataxia-telangiectasia mutated (ATM) upon DNA damage involves a
cascade of reactions, including acetylation by TIP60 and autophosphorylation. However …

DNA damage repair (DDR) is a double-edged sword with different roles in cancer
susceptibility and drug resistance. Recent studies suggest that DDR inhibitors affect immune …

NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress
response, genome integrity, metabolism and aging, while how it is transcriptionally …

SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent
histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but …

Background Radiotherapy (RT) is considered an important therapeutic strategy in the fight
against colorectal cancer (CRC). However, the existence of some radioresistance factors …

Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy,
immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major …