Stocking the toolbox—Using preclinical models to understand the development and treatment of immune checkpoint inhibitor‐induced immune‐related adverse …

ML Cina, J Venegas, A Young - Immunological Reviews, 2023 - Wiley Online Library
Cancer patients treated with immune checkpoint inhibitors (ICIs) are susceptible to a broad
and variable array of immune‐related adverse events (irAEs). With increasing clinical use of …

[HTML][HTML] Immune checkpoint inhibitors as a threat to reproductive function: A systematic review

Y Zhao, Y Li, X Liu, S Wen, J Cao, J Cui… - Critical Reviews in …, 2023 - Elsevier
In recent years, the indications for immunotherapy in cancer treatment have been
expanding. The increased risk of cancer in young people, coupled with the fact that many …

Clonally expanded, thyrotoxic effector CD8+ T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis

MG Lechner, Z Zhou, AT Hoang, N Huang… - Science translational …, 2023 - science.org
Autoimmune toxicity occurs in up to 60% of patients treated with immune checkpoint inhibitor
(ICI) therapy for cancer and represents an increasing clinical challenge for expanding the …

Subclinical central hypothyroidism in patients with hypothalamic-pituitary disease: does it exist?

J Abucham, M Martins - Reviews in Endocrine and Metabolic Disorders, 2024 - Springer
Central hypothyroidism (CH) is characterized by decreased thyroid hormone production due
to insufficient stimulation of an otherwise normal thyroid gland by TSH. In patients with …

Unveiling the etiopathogenic spectrum of hypophysitis: A narrative review

S Menotti, A Giampietro, S Raia, M Veleno… - Journal of Personalized …, 2023 - mdpi.com
Hypophysitis, a rare inflammatory disorder of the pituitary gland, has seen an uptick in
reported cases in recent years. Our objective is to summarize the most recent research on …

Non-Invasive Predictive Biomarkers for Immune-Related Adverse Events Due to Immune Checkpoint Inhibitors

B Ponvilawan, AW Khan, J Subramanian, D Bansal - Cancers, 2024 - mdpi.com
Simple Summary Immune-related adverse events (irAEs) are one of the most common
complications after cancer treatment caused by immune checkpoint inhibitors (ICIs). We …

The molecular basis of hypoprolactinaemia

BP Finn, MT Dattani - Reviews in Endocrine and Metabolic Disorders, 2024 - Springer
Hypoprolactinaemia is an endocrinopathy which is typically encountered as part of a
combined pituitary hormone deficiency picture. The vast majority of genetic causes identified …

Imaging for assessment of cancer treatment response to immune checkpoint inhibitors can be complementary in identifying hypophysitis

A Galligan, A Iravani, A Lasocki, R Wallace… - Frontiers in …, 2023 - frontiersin.org
Introduction Hypophysitis is reported in 8.5%–14% of patients receiving combination
immune checkpoint inhibition (cICI) but can be a diagnostic challenge. This study aimed to …

Sicca syndrome/Sjögren's disease associated with cancer immunotherapy: a narrative review on clinical presentation, biomarkers and management

SG Pasoto, AS Franco, CA Silva… - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Almost one-quarter of immune checkpoint inhibitor (ICI) recipients experience
sicca syndrome, while Sjögren's disease (SjD) is estimated at 0.3-2.5%, possibly …

Immune checkpoint inhibitor induced hypophysitis: a specific disease of corticotrophs?

N Patel, K Hirwa, G Gardner, K Pearce… - Endocrine …, 2024 - ec.bioscientifica.com
Introduction The aim of this study was to define functional and anatomical pituitary disease
at the time of presentation following immune checkpoint inhibitor (ICI) therapy and to …