RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the
nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent …

To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …

Experimental studies reported biochemical actions underpinning aging processes and
mortality, but the relevant metabolic alterations in humans are not well understood. Here we …

Aberrant RNA modifications are frequently associated with cancers, while the underlying
mechanisms and clinical significance remain poorly understood. Here, we find that the ac4C …

Cell fate transition involves dynamic changes of gene regulatory network and chromatin
landscape, requiring multiple levels of regulation, yet the cross-talk between …

Abstract NAT10-catalyzed N4-acetylcytidine (ac4C) has emerged as a vital post-
transcriptional modulator on the coding transcriptome by promoting mRNA stability …

Post-transcriptional RNA modifications critically regulate various biological processes. N 4-
acetylcytidine (ac4C) is an epi-transcriptome, which is highly conserved in all species …

RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that
influences a wide array of biological processes in mesenchymal stem cells (MSCs). These …

As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA
modification processes have been reported, and they are widely present in every organism …