Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

In vitro human digestion models for food applications

SJ Hur, BO Lim, EA Decker, DJ McClements - Food chemistry, 2011 - Elsevier
In vitro digestion models are widely used to study the structural changes, digestibility, and
release of food components under simulated gastrointestinal conditions. However, the …

Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies

CW Pouton, CJH Porter - Advanced drug delivery reviews, 2008 - Elsevier
Oral lipid-based drug delivery systems may include a broad range of oils, surfactants, and
cosolvents. This diversity makes comparison of lipid-based formulations difficult. Although …

Review of in vitro digestion models for rapid screening of emulsion-based systems

DJ McClements, Y Li - Food & function, 2010 - pubs.rsc.org
There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …

Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability

K Kohli, S Chopra, D Dhar, S Arora, RK Khar - Drug discovery today, 2010 - Elsevier
Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …

Enhancing intestinal drug solubilisation using lipid-based delivery systems

CJH Porter, CW Pouton, JF Cuine… - Advanced drug delivery …, 2008 - Elsevier
Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …

[HTML][HTML] Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: A review

S Sambhakar, R Saharan, S Narwal, R Malik… - Saudi Pharmaceutical …, 2023 - Elsevier
This review aims to provide a thorough examination of the benefits, challenges, and
advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the …

Oral lipid-based formulations

DJ Hauss - Advanced drug delivery reviews, 2007 - Elsevier
Poor drug solubility remains a significant and frequently encountered problem for
pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal …

Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems

J Kuntsche, JC Horst, H Bunjes - International journal of pharmaceutics, 2011 - Elsevier
Cryogenic transmission electron microscopy (cryo-TEM) has evolved into an indispensable
tool for the characterization of colloidal drug delivery systems. It can be applied to study the …

Lipid–an emerging platform for oral delivery of drugs with poor bioavailability

S Chakraborty, D Shukla, B Mishra, S Singh - European journal of …, 2009 - Elsevier
The sole objective of pharmaceutical science is to design successful dosage forms which
fulfill the therapeutic needs of the patients effectively. Development of new drug entities is …