Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
In vitro human digestion models for food applications
In vitro digestion models are widely used to study the structural changes, digestibility, and
release of food components under simulated gastrointestinal conditions. However, the …
release of food components under simulated gastrointestinal conditions. However, the …
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies
CW Pouton, CJH Porter - Advanced drug delivery reviews, 2008 - Elsevier
Oral lipid-based drug delivery systems may include a broad range of oils, surfactants, and
cosolvents. This diversity makes comparison of lipid-based formulations difficult. Although …
cosolvents. This diversity makes comparison of lipid-based formulations difficult. Although …
Review of in vitro digestion models for rapid screening of emulsion-based systems
DJ McClements, Y Li - Food & function, 2010 - pubs.rsc.org
There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …
Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …
Enhancing intestinal drug solubilisation using lipid-based delivery systems
CJH Porter, CW Pouton, JF Cuine… - Advanced drug delivery …, 2008 - Elsevier
Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …
[HTML][HTML] Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: A review
S Sambhakar, R Saharan, S Narwal, R Malik… - Saudi Pharmaceutical …, 2023 - Elsevier
This review aims to provide a thorough examination of the benefits, challenges, and
advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the …
advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the …
Oral lipid-based formulations
DJ Hauss - Advanced drug delivery reviews, 2007 - Elsevier
Poor drug solubility remains a significant and frequently encountered problem for
pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal …
pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal …
Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems
J Kuntsche, JC Horst, H Bunjes - International journal of pharmaceutics, 2011 - Elsevier
Cryogenic transmission electron microscopy (cryo-TEM) has evolved into an indispensable
tool for the characterization of colloidal drug delivery systems. It can be applied to study the …
tool for the characterization of colloidal drug delivery systems. It can be applied to study the …
Lipid–an emerging platform for oral delivery of drugs with poor bioavailability
The sole objective of pharmaceutical science is to design successful dosage forms which
fulfill the therapeutic needs of the patients effectively. Development of new drug entities is …
fulfill the therapeutic needs of the patients effectively. Development of new drug entities is …