Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

The field of aging and dementia is focusing on the characterization of the earliest stages of
cognitive impairment. Recent research has identified a transitional state between the …

The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the
prevailing diagnostic standards in research; however, they have now fallen behind the …

Neuropsychological assessment of older individuals with dementing illnesses has suffered
from a lack of appropriately designed test instruments. The Repeatable Battery for the …

Objective To forecast dementia prevalence with a dynamic modelling approach that
integrates calendar trends in dementia incidence with those for mortality and cardiovascular …

Objective: To test the hypothesis that MRI-based measurements of hippocampal volume are
related to the risk of future conversion to Alzheimer's disease (AD) in older patients with a …

Objective Whereas cognitive deficits are known to be detectable long before the typical
symptoms of Alzheimer's disease (AD) are evident, previous studies have failed to …

Cerebral small-vessel disease is common in older people and may contribute to the
development of dementia. The objective of the present study was to evaluate the …

Mild cognitive impairment (MCI) manifests as memory impairment in the absence of
dementia and progresses to Alzheimer's disease (AD) at a rate of around 15% per annum …

Despite general agreement about the boundaries of Alzheimer disease (AD), establishing a
maximum limit for Alzheimer-type pathology in cognitively intact individuals might aid in …