Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …

Chronic inflammation of adipose tissue is a prominent characteristic of many metabolic
diseases. Lipid metabolism in adipose tissue is consistently dysregulated during …

Sarcopenia is a major public health concern among older adults, leading to disabilities, falls,
fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of …

Dysregulation of growth hormone (GH) signaling consistently leads to increased lifespan in
laboratory rodents, yet the precise mechanisms driving this extension remain unclear …

Aging coincides with the progressive loss of muscle mass and strength, increased adiposity,
and diminished physical function. Accordingly, interventions aimed at improving muscle …

Among the inherited myopathies, a group of muscular disorders characterized by structural
and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands …

Sphingosine-1-phosphate lyase (SPL) resides at the endpoint of the sphingolipid metabolic
pathway, catalyzing the irreversible breakdown of sphingosine-1-phosphate. Depletion of …

Duchenne muscular dystrophy (DMD), a severe X-linked inherited neuromuscular disease,
has a high prevalence of obesity. Obesity exacerbates muscle damage and results in …

The global prevalence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is
rapidly increasing, revealing a strong association between these two diseases. Currently …

Objective Emerging studies have revealed that macrophages possess different
dependences on the uptake, synthesis, and metabolism of serine for their activation and …