Bile acids as modulators of gut microbiota composition and function

AB Larabi, HLP Masson, AJ Bäumler - Gut Microbes, 2023 - Taylor & Francis
Changes in the composition of gut-associated microbial communities are associated with
many human illnesses, but the factors driving dysbiosis remain incompletely understood …

Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis

J Wang, N Zhu, X Su, Y Gao, R Yang - Cells, 2023 - mdpi.com
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

W Yang, Y Cong - Cellular & molecular immunology, 2021 - nature.com
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

W Jia, G Xie, W Jia - Nature reviews Gastroenterology & hepatology, 2018 - nature.com
Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

Bile acids and their receptors in metabolic disorders

S Fiorucci, E Distrutti, A Carino, A Zampella… - Progress in Lipid …, 2021 - Elsevier
Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Bile acids activated receptors regulate innate immunity

S Fiorucci, M Biagioli, A Zampella… - Frontiers in …, 2018 - frontiersin.org
Once known exclusively for their role in nutrients absorption, primary bile acids,
chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic …

Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome

C Guo, S Xie, Z Chi, J Zhang, Y Liu, L Zhang, M Zheng… - Immunity, 2016 - cell.com
Reciprocal interactions between the metabolic system and immune cells play pivotal roles in
diverse inflammatory diseases, but the underlying mechanisms remain elusive. The …

[HTML][HTML] Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling

J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan… - Cell reports, 2021 - cell.com
Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy
balance and host metabolism via G protein-coupled receptors and/or nuclear receptors …

Mining the microbiota for microbial and metabolite-based immunotherapies

AN Skelly, Y Sato, S Kearney, K Honda - Nature Reviews Immunology, 2019 - nature.com
Trillions of microorganisms transit through and reside in the mammalian gastrointestinal tract
each day, collectively producing thousands of small molecules and metabolites with local …