Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

One of the main functions of mitochondria is production of ATP for cellular energy needs,
however, it becomes more recognized that mitochondria are involved in differentiation and …

Like other autoimmune diseases, rheumatoid arthritis (RA) develops in distinct stages, with
each phase of disease linked to immune cell dysfunction. HLA class II genes confer the …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …

In eukaryotic cells, protein sorting is a highly regulated mechanism important for many
physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi …

The secretory properties of cancer-associated fibroblasts (CAFs) play predominant roles in
shaping a pro-metastatic tumor microenvironment. The present study demonstrated that …

Cell migration entails networks and bundles of actin filaments termed lamellipodia and
microspikes or filopodia, respectively, as well as focal adhesions, all of which recruit …

Highlights•Actin polymerization on endosomes is primarily controlled by the regulation of the
WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and …

Actin filaments play multiple roles in the secretory pathway and in endosome dynamics in
mammals, including maintenance of Golgi structure, release of membrane cargo from the …