Emerging SARS-CoV-2 variants of concern (VOCs): an impending global crisis

AYK Thye, JWF Law, P Pusparajah, V Letchumanan… - Biomedicines, 2021 - mdpi.com
The worldwide battle against the SARS-CoV-2 virus rages on, with millions infected and
many innocent lives lost. The causative organism, severe acute respiratory syndrome …

The ins and outs of SARS-CoV-2 variants of concern (VOCs)

M Salehi-Vaziri, M Fazlalipour, SM Seyed Khorrami… - Archives of …, 2022 - Springer
Abstract SARS-CoV-2, a newly emerging coronavirus that caused the COVID-19 epidemic,
has been spreading quickly throughout the world. Despite immunization and some fairly …

Small drugs, huge impact: the extraordinary impact of antisense oligonucleotides in research and drug development

AM Quemener, ML Centomo, SL Sax, R Panella - Molecules, 2022 - mdpi.com
Antisense oligonucleotides (ASOs) are an increasingly represented class of drugs. These
small sequences of nucleotides are designed to precisely target other oligonucleotides …

[HTML][HTML] Detection of SARS-CoV-2 lineage P. 1 in patients from a region with exponentially increasing hospitalisation rate, February 2021, Rio Grande do Sul …

AF Martins, AP Zavascki, PL Wink… - …, 2021 - eurosurveillance.org
The emergence of SARS-CoV-2 P. 1 lineage coincided with a surge in hospitalisations in
the North region of Brazil. In the South region's Rio Grande do Sul state, severe COVID-19 …

SARS-CoV-2 variants: a synopsis of in vitro efficacy data of convalescent plasma, currently marketed vaccines, and monoclonal antibodies

D Focosi, M Tuccori, A Baj, F Maggi - Viruses, 2021 - mdpi.com
We summarize here in vitro evidences of efficacy for convalescent plasma, currently
approved vaccines and monoclonal antibodies against SARS-CoV-2 variants of concern …

Infection control, occupational and public health measures including mRNA-based vaccination against SARS-CoV-2 infections to protect healthcare workers from …

A Yassi, JM Grant, K Lockhart, S Barker, S Sprague… - PLoS …, 2021 - journals.plos.org
Background We evaluated measures to protect healthcare workers (HCWs) in Vancouver,
Canada, where variants of concern (VOC) went from< 1% VOC in February 2021 to> 92% in …

Mutation induced infection waves in diseases like COVID-19

FJ Schwarzendahl, J Grauer, B Liebchen, H Löwen - Scientific Reports, 2022 - nature.com
After more than 6 million deaths worldwide, the ongoing vaccination to conquer the COVID-
19 disease is now competing with the emergence of increasingly contagious mutations …

The unexpected dynamics of COVID-19 in Manaus, Brazil: Was herd immunity achieved?

D He, Y Artzy-Randrup, SS Musa, T Gräf, F Naveca… - MedRxiv, 2021 - medrxiv.org
Abstract In late March 2020, SARS-CoV-2 arrived in Manaus, Brazil, and rapidly developed
into a large-scale epidemic that collapsed the local health system, and resulted in extreme …

Simulating immunization campaigns and vaccine protection against COVID-19 pandemic in Brazil

F Amaral, W Casaca, CM Oishi, JA Cuminato - IEEE Access, 2021 - ieeexplore.ieee.org
The vaccine roll-out has currently established a new trend in the fight against COVID-19. In
many countries, as vaccination cover rises, the economic and social disruptions are being …

Epidemic spreading under mutually independent intra-and inter-host pathogen evolution

X Zhang, Z Ruan, M Zheng, J Zhou, S Boccaletti… - Nature …, 2022 - nature.com
The dynamics of epidemic spreading is often reduced to the single control parameter R 0
(reproduction-rate), whose value, above or below unity, determines the state of the …