Practice recommendations for diagnosis and treatment of the most common forms of secondary hypertension

GP Rossi, V Bisogni, G Rossitto, G Maiolino… - High Blood Pressure & …, 2020 - Springer
The vast majority of hypertensive patients are never sought for a cause of their high blood
pressure, ie for a 'secondary'form of arterial hypertension. This under detection explains why …

The effect of aldosterone on cardiorenal and metabolic systems

H Otsuka, M Abe, H Kobayashi - International journal of molecular …, 2023 - mdpi.com
Aldosterone, a vital hormone of the human body, has various pathophysiological roles. The
excess of aldosterone, also known as primary aldosteronism, is the most common …

The unrecognized prevalence of primary aldosteronism: a cross-sectional study

JM Brown, M Siddiqui, DA Calhoun… - Annals of Internal …, 2020 - acpjournals.org
Background: Primary aldosteronism is a nonsuppressible renin-independent aldosterone
production that causes hypertension and cardiovascular disease. Objective: To characterize …

Testing for primary aldosteronism and mineralocorticoid receptor antagonist use among US veterans: a retrospective cohort study

JB Cohen, DL Cohen, DS Herman… - Annals of internal …, 2021 - acpjournals.org
Background: Primary aldosteronism is a common cause of treatment-resistant hypertension.
However, evidence from local health systems suggests low rates of testing for primary …

Clinical outcomes of 1625 patients with primary aldosteronism subtyped with adrenal vein sampling

GP Rossi, G Rossitto, L Amar, M Azizi, A Riester… - …, 2019 - Am Heart Assoc
We sought to measure the clinical benefits of adrenal venous sampling (AVS), a test
recommended by guidelines for primary aldosteronism (PA) patients seeking surgical cure …

Intraindividual variability of aldosterone concentrations in primary aldosteronism: implications for case detection

N Yozamp, GL Hundemer, M Moussa, J Underhill… - …, 2021 - Am Heart Assoc
Primary aldosteronism is an underdiagnosed cause of hypertension. Although inadequate
screening is one reason for underdiagnosis, another important contributor is that clinicians …

Primary aldosteronism diagnosis and management: a clinical approach

GL Hundemer, A Vaidya - Endocrinology and Metabolism …, 2019 - endo.theclinics.com
Primary aldosteronism used to be considered a rare cause of secondary hypertension.
However, accruing evidence indicates that primary aldosteronism is more common than …

Treating primary aldosteronism-induced hypertension: novel approaches and future outlooks

N Mullen, J Curneen, PT Donlon, P Prakash… - Endocrine …, 2024 - academic.oup.com
Primary aldosteronism (PA) is the most common cause of secondary hypertension and is
associated with increased morbidity and mortality when compared with blood pressure …

Mineralocorticoid receptors in metabolic syndrome: from physiology to disease

A Feraco, V Marzolla, A Scuteri, A Armani… - Trends in Endocrinology …, 2020 - cell.com
Over the past decade, several studies have shown that activity of extra-renal
mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue …

Heightened cardiovascular risk in hypertension associated with renin‐independent aldosteronism versus renin‐dependent aldosteronism: a collaborative study

J Hu, H Shen, P Huo, J Yang, PJ Fuller… - Journal of the …, 2021 - Am Heart Assoc
Background While both renin‐dependent and renin‐independent aldosterone secretion
contribute to aldosteronism, their relative associations with cardiovascular disease (CVD) …