Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

Pathogen-associated molecular patterns (PAMPs) and endogenous “danger” signals,
known as danger-associated molecular patterns (DAMPs), released from cells alert the …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

The members of the chromogranin–secretogranin family of peptide hormones, biogenic
amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system …

Glia undergo inflammatory activation in most CNS pathologies and are capable of killing
cocultured neurons. We investigated the mechanisms of this inflammatory …

Neuroinflammation is a host‐defense mechanism associated with restoration of normal
structure and function of the brain and neutralization of an insult. Increasing …

Background The role of both microglial activation and alpha-synuclein deposition in
Parkinson's disease remain unclear. We have tested the hypothesis that if microglia play a …

Microglial cells are believed to play an active role in brain inflammatory, immune and
degenerative processes. Depending on the magnitude of microglial reaction, on the type of …