Transcription factor networks have evolved in order to control, coordinate, and separate, the
functions of distinct network modules spatially and temporally. In this review we focus on the …

Metabolic reprogramming is a hallmark of cancer cells and contributes to their adaption
within the tumour microenvironment and resistance to anticancer therapies. Recently …

Liver glycogen is synthesized after a meal in response to an increase in blood glucose
concentration in the portal vein and endocrine and neuroendocrine signals, and is degraded …

Glucose is an energy source that also controls the expression of key genes involved in
energetic metabolism through the glucose-signaling transcription factor carbohydrate …

The hepatic glucose-sensing system is a functional network of enzymes and transcription
factors that is critical for the maintenance of energy homeostasis and systemic glycemia …

The Myc Network, comprising a small assemblage of bHLH-ZIP transcription factors,
regulates many hundreds to thousands of genes involved in proliferation, energy …

Human MondoA requires glucose as well as other modulatory signals to function in
transcription. One such signal is acidosis, which increases MondoA activity and also drives a …

Intramuscular lipid accumulation is a common manifestation of chronic caloric excess and
obesity that is strongly associated with insulin resistance. The mechanistic links between …

Identification of the Mondo glucose-responsive transcription factors family, including the
MondoA and MondoB/ChREBP paralogs, has shed light on the mechanism whereby …

Liver glucose metabolism is dependent on glucokinase activity. Glucokinase expression is
transcriptionally regulated by hormones and metabolites of glucose, and glucokinase activity …