Base excision repair: a critical player in many games
SS Wallace - DNA repair, 2014 - Elsevier
This perspective reviews the many dimensions of base excision repair from a 10,000 foot
vantage point and provides one person's view on where the field is headed. Enzyme …
vantage point and provides one person's view on where the field is headed. Enzyme …
Oxidative stress-modulating drugs have preferential anticancer effects-involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy …
To achieve preferential effects against cancer cells but less damage to normal cells is one of
the main challenges of cancer research. In this review, we explore the roles and …
the main challenges of cancer research. In this review, we explore the roles and …
RNA therapeutics-research and clinical advancements
R Feng, S Patil, X Zhao, Z Miao, A Qian - Frontiers in Molecular …, 2021 - frontiersin.org
RNA therapeutics involve the use of coding RNA such as mRNA as well as non-coding
RNAs such as small interfering RNAs (siRNA), antisense oligonucleotides (ASO) to target …
RNAs such as small interfering RNAs (siRNA), antisense oligonucleotides (ASO) to target …
A BRCA 1‐interacting lnc RNA regulates homologous recombination
Long non‐coding RNA s (lnc RNA s) are important players in diverse biological processes.
Upon DNA damage, cells activate a complex signaling cascade referred to as the DNA …
Upon DNA damage, cells activate a complex signaling cascade referred to as the DNA …
LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia
S Emmrich, A Streltsov, F Schmidt, VR Thangapandi… - Molecular cancer, 2014 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are recognized as pivotal players
during developmental ontogenesis and pathogenesis of cancer. The intronic microRNA …
during developmental ontogenesis and pathogenesis of cancer. The intronic microRNA …
Can epigenetics translate environmental cues into phenotypes?
P Norouzitallab, K Baruah, D Vanrompay… - Science of the Total …, 2019 - Elsevier
Living organisms are constantly exposed to wide ranges of environmental cues. They react
to these cues by undergoing a battery of phenotypic responses, such as by altering their …
to these cues by undergoing a battery of phenotypic responses, such as by altering their …
Endoplasmic reticulum stress, genome damage, and cancer
N Dicks, K Gutierrez, M Michalak, V Bordignon… - Frontiers in …, 2015 - frontiersin.org
Endoplasmic reticulum (ER) stress has been linked to many diseases, including cancer. A
large body of work has focused on the activation of the ER stress response in cancer cells to …
large body of work has focused on the activation of the ER stress response in cancer cells to …
Role of LncRNAs and CircRNAs in bone metabolism and osteoporosis
S Patil, K Dang, X Zhao, Y Gao, A Qian - Frontiers in genetics, 2020 - frontiersin.org
Bone is a mechanosensitive organ that provides strength and support. Many bone cells,
various pathways, and signaling molecules coordinate bone metabolism and also determine …
various pathways, and signaling molecules coordinate bone metabolism and also determine …
Protective effects of bovine milk exosomes against oxidative stress in IEC-6 cells
L Wang, Z Shi, X Wang, S Mu, X Xu, L Shen… - European journal of …, 2021 - Springer
Purpose Bovine milk exosomes, which are enriched with microRNAs (miRNAs) and
proteins, regulate immune response and growth. In the present study, we aimed to assess …
proteins, regulate immune response and growth. In the present study, we aimed to assess …
The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression
Posttranscriptional maturation is a critical step in microRNA (miRNA) biogenesis that
determines mature miRNA levels. In addition to core components (Drosha and DGCR8 …
determines mature miRNA levels. In addition to core components (Drosha and DGCR8 …