Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Advances in the role of STAT3 in macrophage polarization

T Xia, M Zhang, W Lei, R Yang, S Fu, Z Fan… - Frontiers in …, 2023 - frontiersin.org
The physiological processes of cell growth, proliferation, differentiation, and apoptosis are
closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has …

The metabolic signature of macrophage responses

A Viola, F Munari, R Sánchez-Rodríguez… - Frontiers in …, 2019 - frontiersin.org
Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Major pathways involved in macrophage polarization in cancer

C Kerneur, CE Cano, D Olive - Frontiers in immunology, 2022 - frontiersin.org
Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …

Liver regeneration and inflammation: from fundamental science to clinical applications

L Campana, H Esser, M Huch, S Forbes - Nature reviews Molecular cell …, 2021 - nature.com
Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Macrophage reprogramming and cancer therapeutics: role of iNOS-derived NO

K Kashfi, J Kannikal, N Nath - Cells, 2021 - mdpi.com
Nitric oxide and its production by iNOS is an established mechanism critical to tumor
promotion or suppression. Macrophages have important roles in immunity, development …

Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19

Q Tao, J Du, X Li, J Zeng, B Tan, J Xu… - Drug development and …, 2020 - Taylor & Francis
Abstract Purpose Huashi Baidu formula (HSBDF) was developed to treat the patients with
severe COVID-19 in China. The purpose of this study was to explore its active compounds …

Macrophages and the recovery from acute and chronic inflammation

K Hamidzadeh, SM Christensen, E Dalby… - Annual review of …, 2017 - annualreviews.org
In recent years, researchers have devoted much attention to the diverse roles of
macrophages and their contributions to tissue development, wound healing, and …

The gut microbiome, kidney disease, and targeted interventions

A Ramezani, DS Raj - Journal of the American Society of …, 2014 - journals.lww.com
The human gut harbors> 100 trillion microbial cells, which influence the nutrition,
metabolism, physiology, and immune function of the host. Here, we review the quantitative …

The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ

X Wang, Y Ji, P Feng, R Liu, G Li, J Zheng… - Advanced …, 2021 - Wiley Online Library
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue
microenvironment. Currently, little is known about how the intrinsic regulators modulate …