Viral infection of mammalian cells rapidly triggers intracellular signalling events leading to
interferon α/β production and a cellular antiviral state. This 'host response'is our first line of …

Recent evidence indicates a convergence of molecular targets for both prevention and
therapy of cancer. Signal‐transducer‐and‐activator‐of‐transcription‐3 (STAT3), a member …

BACKGROUND & AIMS: Bcl-xL, an anti-apoptotic member of the Bcl-2 family, is over-
expressed in human hepatocellular carcinoma, conferring a survival advantage to tumour …

The complexity of multicellular organisms is dependent on systems enabling cells to
respond to specific stimuli. Cytokines and their receptors are one such system, whose …

Apoptosis is central for the control and elimination of viral infections. In chronic hepatitis C
virus (HCV) infection, enhanced hepatocyte apoptosis and upregulation of the death …

The hepatitis C virus (HCV) nonstructural NS5A protein has been shown to bind to and
activate phosphoinositide 3-kinase (PI3K), resulting in activation of the downstream effector …

Chronic hepatitis C virus (HCV) infection is a major risk factor for liver disease progression,
and may lead to cirrhosis and hepatocellular carcinoma (HCC). The HCV genome contains …

BACKGROUND/AIMS: The hepatitis C virus (HCV) structural core and non-structural NS5A
proteins induce in liver cells a series of intracellular events, including elevation of reactive …

Signal transducer and activator of transcription 3 (STAT3) has been reported to be activated
by interleukin-6 receptor (IL-6R) or epidermal growth factor receptor (EGFR) in head and …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which can
be activated by cytokines, growth factor receptors, and nonreceptor-like tyrosine kinase. An …