Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

As sessile organisms, plants evolved elaborate metabolic systems that produce a plethora of
specialized metabolites as a means to survive challenging terrestrial environments …

Metabolons, multiprotein complexes consisting of sequential enzymes of a metabolic
pathway, are proposed to be biosynthetic “hotspots” within the cell. However, experimental …

With the elucidation of myriad anabolic and catabolic enzyme-catalyzed cellular pathways
crisscrossing each other, an obvious question arose: how could these networks operate with …

Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …

The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …

Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

Over the past fifteen years, we have unveiled a new mechanism by which cells achieve
greater efficiency in de novo purine biosynthesis. This mechanism relies on the …

Nucleotides are essential to cell growth and survival, providing cells with building blocks for
DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the …