Cell–extracellular matrix mechanotransduction in 3D

A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Crosstalk between mechanotransduction and metabolism

P Romani, L Valcarcel-Jimenez, C Frezza… - … Reviews Molecular Cell …, 2021 - nature.com
Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Mesenchymal stem cell perspective: cell biology to clinical progress

MF Pittenger, DE Discher, BM Péault… - NPJ Regenerative …, 2019 - nature.com
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …

Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

Mechanical forces direct stem cell behaviour in development and regeneration

KH Vining, DJ Mooney - Nature reviews Molecular cell biology, 2017 - nature.com
Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

Modeling physiological events in 2D vs. 3D cell culture

K Duval, H Grover, LH Han, Y Mou… - …, 2017 - journals.physiology.org
Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …

Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues

S Tang, BM Richardson, KS Anseth - Progress in Materials Science, 2021 - Elsevier
The extracellular matrix (ECM) and its mechanical properties play an important role in
regulating the cellular responses that occur during tissue regeneration, wound healing, and …

Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G Jin… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

G Burgstaller, B Oehrle, M Gerckens… - European …, 2017 - Eur Respiratory Soc
The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …

YAP/TAZ functions and their regulation at a glance

A Pocaterra, P Romani, S Dupont - Journal of cell science, 2020 - journals.biologists.com
ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …