The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

Lysine acetylation has emerged as a major posttranslational modification for histones.
Crossregulation between this and other modifications is crucial in modulating chromatin …

The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

The p53 tumor suppressor protein is a DNA sequence-specific transcriptional regulator that,
in response to various forms of cellular stress, controls the expression of numerous genes …

The tumor suppressor protein p53 is inactivated by mutation in about half of all human
cancers. Most mutations are located in the DNA-binding domain of the protein. It is …

Oncogenesis is a multistep process mediated by a variety of factors including epigenetic
modifications. Global epigenetic post-translational modifications have been detected in …

Type III effector proteins from bacterial pathogens manipulate components of host immunity
to suppress defence responses and promote pathogen development. In plants, host proteins …

DNA binding by numerous transcription factors including the p53 tumor suppressor protein
constitutes a vital early step in transcriptional activation. While the role of the central core …