Novel evidence on sepsis-inducing pathogens: from laboratory to bedside

S Gatica, B Fuentes, E Rivera-Asín… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening condition and a significant cause of preventable morbidity and
mortality globally. Among the leading causative agents of sepsis are bacterial pathogens …

Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?

Z Liang, Y Wang, Y Lai, J Zhang, L Yin, X Yu… - Frontiers in Cellular …, 2022 - frontiersin.org
Klebsiella pneumonia e (K. pneumoniae) is a typical gram-negative iatrogenic bacterium
that often causes bacteremia, pneumonia and urinary tract infection particularly among …

Hypoxia inducible factor-1 signaling pathway in macrophage involved angiogenesis in materials-instructed osteo-induction

H Bai, X Guo, Y Tan, Y Wang, J Feng, K Lei… - Journal of Materials …, 2022 - pubs.rsc.org
Although osteo-inductive materials are regarded as promising candidates for critical-sized
bone repair, their clinical application is limited by ambiguous mechanisms. The hypoxia …

Animal models of Klebsiella pneumoniae mucosal infections

L Assoni, AJM Couto, B Vieira, B Milani… - Frontiers in …, 2024 - frontiersin.org
Klebsiella pneumoniae is among the most relevant pathogens worldwide, causing high
morbidity and mortality, which is worsened by the increasing rates of antibiotic resistance. It …

Role of Hypoxia-inducible factor 1α in host defense during pneumococcal pneumonia

L Pereverzeva, NA Otto, H Peters-Sengers… - Pathogens and …, 2023 - academic.oup.com
Abstract Hypoxia-inducible factor (HIF) 1α is a transcription factor involved in cellular
metabolism and regulation of immune cell effector functions. Here, we studied the role of …

[PDF][PDF] Animal models of Klebsiella

L Assoni, AJM Couto, B Vieira, B Milani, AS Lima… - 2024 - frontiersin.org
Klebsiella pneumoniae is a widely distributed bacterium that colonizes the human skin,
mouth, respiratory and gastrointestinal (GI) tracts asymptomatically. It is also one of the main …

Cigarette smoke-induced airspace disease in mice develops independently of HIF-1α signaling in leukocytes

PS Hume, J McClendon, KW Kopf… - … of Physiology-Lung …, 2022 - journals.physiology.org
The pathogenesis of chronic obstructive pulmonary disease (COPD), a prevalent disease
primarily caused by cigarette smoke exposure, is incompletely elucidated. Studies in …

Human Transcriptome Array Analysis Identifies CDR2 as a Novel Suppressed Gene for Kawasaki Disease

YH Huang, KD Chen, KC Kuo, MMH Guo, LS Chang… - Diagnostics, 2022 - mdpi.com
Kawasaki disease (KD) is a febrile childhood vasculitis that involves the coronary arteries.
Most previous studies have focused on the genes activated in the acute phase of KD …

[PDF][PDF] Coincidencia entre la periodontitis y la enfermedad inflamatoria del intestino

BE Falcón-Guerrero - Revista KIRU, 2023 - researchgate.net
Tras una investigación hecha en los últimos años se ha demostrado que la enfermedad
periodontal y la enfermedad inflamatoria intestinal pueden desarrollarse, ya que esta es …