Background Neuroimaging studies help us better understand the pathophysiology and
symptoms of Parkinson's disease (PD). In several of these studies, diffusion tensor imaging …

Objectives: We performed a systematic review to assess alterations in measures of diffusion
tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in …

Parkinson's disease involves multiple neurotransmitter systems beyond the classical
dopaminergic circuit, but their influence on structural and functional alterations is not well …

Conventional single tensor diffusion analysis models have provided mixed findings in the
substantia nigra of Parkinson's disease, but recent work using a bi-tensor analysis model …

Neurite orientation dispersion and density imaging (NODDI) uses a three‐compartment
model to probe brain tissue microstructure, whereas free‐water (FW) imaging models two …

Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra
of Parkinson's disease. It is the case, however, that partial volume effects from free water can …

The spectrum of cognitive symptoms in Parkinson's disease (PD) can span various domains,
including executive function, language, attention, memory, and visuospatial skills. These …

METHODS Historically, most neuroimaging studies of the human brain have employed a
modular view of the brain, eg, region X is responsible for function Y. This modularity of mind …

To date, the most frequently used Parkinson's disease (PD) biomarkers are the brain
imaging measures of dopaminergic dysfunction using positron emission tomography and …

A progressive loss of dopamine neurons in the substantia nigra (SN) is considered the main
feature of idiopathic Parkinson's disease (PD). Recent neuropathological evidence however …