Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

Importance The prognostic role of high blood pressure and the aggressiveness of blood
pressure lowering in dementia are not well characterized. Objective To assess whether …

While prevailing evidence supports that the amyloid cascade hypothesis is a key component
of Alzheimer's disease (AD) pathology, many recent studies indicate that the vascular …

Observational epidemiological studies provide valuable information regarding naturally
occurring protective factors observed in populations with very low prevalences of vascular …

Hypertension and stroke are highly prevalent risk factors for cognitive impairment and
dementia. Alzheimer's disease (AD) and vascular dementia (VaD) are the most common …

There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVR CO 2) is
impaired in Alzheimer's disease (AD). Preclinical and animal studies suggest chronic …

Cerebral blood flow, arterial pulsation, and vasomotion play important roles in the transport
of waste metabolites out of the brain. Impaired vasomotion results in reduced driving force …

Alzheimer's disease (AD) is the most common form of dementia manifesting as alterations in
cognitive abilities, behavior, and deterioration in memory which is progressive, leading to …

Background Understanding the relationship between vascular disease and Alzheimer's
disease (AD) will enhance our insight into this disease and pave the way for novel …