Staphylococcus aureus pathogenesis in diverse host environments

D Balasubramanian, L Harper, B Shopsin… - Pathogens and …, 2017 - academic.oup.com
Staphylococcus aureus is an eminent human pathogen that can colonize the human host
and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide …

Inside job: Staphylococcus aureus host-pathogen interactions

J Horn, K Stelzner, T Rudel, M Fraunholz - International Journal of Medical …, 2018 - Elsevier
Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of
diseases. Recent research established that once phagocytosed by neutrophils and …

The SaeRS Two-Component System of Staphylococcus aureus

Q Liu, WS Yeo, T Bae - Genes, 2016 - mdpi.com
In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS two-
component system (TCS) plays a major role in controlling the production of over 20 …

The bicomponent pore-forming leucocidins of Staphylococcus aureus

F Alonzo III, VJ Torres - Microbiology and Molecular Biology …, 2014 - Am Soc Microbiol
The ability to produce water-soluble proteins with the capacity to oligomerize and form pores
within cellular lipid bilayers is a trait conserved among nearly all forms of life, including …

Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus

FE Guerra, TR Borgogna, DM Patel… - Frontiers in cellular …, 2017 - frontiersin.org
Neutrophils are the most abundant leukocytes in human blood and the first line of defense
after bacteria have breached the epithelial barriers. After migration to a site of infection …

Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective

CP Gordon, P Williams, WC Chan - Journal of medicinal chemistry, 2013 - ACS Publications
Virulence gene expression in Staphylococcus aureus is tightly regulated by intricate
networks of transcriptional regulators and two-component signal transduction systems …

The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response

A Delauné, S Dubrac, C Blanchet, O Poupel… - Infection and …, 2012 - Am Soc Microbiol
The WalKR two-component system is essential for the viability of Staphylococcus aureus,
playing a central role in controlling cell wall metabolism. We produced a constitutively active …

Staphylococcus aureus induces a muted host response in human blood that blunts the recruitment of neutrophils

EE Zwack, Z Chen, JC Devlin, Z Li… - Proceedings of the …, 2022 - National Acad Sciences
Staphylococcus aureus is an opportunistic pathogen and chief among bloodstream-infecting
bacteria. S. aureus produces an array of human-specific virulence factors that may …

The Role of Two-Component Signal Transduction Systems in Staphylococcus aureus Virulence Regulation

AF Haag, F Bagnoli - Staphylococcus aureus: Microbiology, Pathology …, 2017 - Springer
Staphylococcus aureus is a versatile, opportunistic human pathogen that can
asymptomatically colonize a human host but can also cause a variety of cutaneous and …

Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI‐carried variants of von Willebrand factor‐binding protein

D Viana, J Blanco, MÁ Tormo‐Más… - Molecular …, 2010 - Wiley Online Library
Staphylococci adapt specifically to various animal hosts by genetically determined
mechanisms that are not well understood. One such adaptation involves the ability to …